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Trump hits McCain and Flake in Arizona without naming them — and appears to relish it

Washington Post - 1 hour 39 min ago
"I will not mention any names. Very presidential, isn't it?" Trump said mockingly.

Hillary Clinton: My 'skin crawled' when Trump stood behind me

CNN - 1 hour 40 min ago
In her upcoming memoir, Hillary Clinton expresses regret and explains what she wishes she could go back and do differently during her failed 2016 campaign, according to excerpts released Wednesday morning.

White House has paperwork ready for Joe Arpaio pardon

CNN - 1 hour 42 min ago
The White House has prepared the paperwork for President Trump to pardon former sheriff Joe Arpaio when he makes the final decision to do so, CNN has learned.

Next stop, Reno: Trump to speak to veterans today

CNN - 1 hour 44 min ago
President Donald Trump has another speech out West on Wednesday, coming just hours after he held a campaign rally in Phoenix, this time with a scheduled stop in Reno, Nevada.

Analysis: Trump could launch a nuclear bomb really fast

CNN - 1 hour 49 min ago
Following President Donald Trump's speech in Arizona on Tuesday, former Director of National Intelligence James Clapper on CNN voiced concerns about Trump's mental stability, particularly in relation to his access to the US nuclear arsenal. "The whole system is built to ensure rapid response if necessary," Clapper said. "So there's very little in the way of controls over exercising a nuclear option, which is pretty damn scary."

Apple TV's Estimated Market Share Declines as Customers Await Highly-Anticipated 4K Model

MacRumors - 1 hour 52 min ago
Apple TV was the fourth most popular streaming media player in the United States in the first quarter, behind the Roku, Amazon's Fire TV, and Google's Chromecast, according to market research firm Parks Associates.

Parks Associates estimates Apple TV's market share fell to 15 percent in January through March this year among U.S. households with broadband. MacRumors confirmed the survey size was 10,306 households.

By comparison, Roku increased its lead in the category to an estimated 37 percent market share in the first quarter, trailed by the Fire TV and Chromecast at an estimated 24 percent and 18 percent respectively.

At $149, the Apple TV is also more expensive than any of its major competitors. Roku starts at $40, Chromecast starts at $35, and Fire TV starts at $90, with even cheaper prices often available from resellers.

"Higher-priced devices, such as the Apple TV, have not been able to keep up with low-priced and readily available Roku devices, which can be found at Walmart for as low as $29.99," said Glenn Hower, Senior Analyst at Parks Associates.

In January, following Apple's first quarter earnings results, financial chief Luca Maestri said Apple TV sales had declined on a year-over-year basis. Exact sales are unknown, as Apple groups the device under its "Other Products" category.

4K on Horizon
The current Apple TV launched in October 2015, ushering in significant changes such as a brand new tvOS operating system, App Store, and a Siri Remote. But, nearly two years have passed, and customers are anxiously awaiting what's next.

One of the most desired features is 4K support, and rumors suggest Apple TV fans may soon have that wish granted.

In February, Bloomberg reported that Apple was testing a new Apple TV with 4K and more vivid colors that could be released as early as later this year. The report said the fifth-generation model is codenamed J105.

The codename, and references to 4K and HDR, have since been found in both the accidentally released HomePod firmware and the seventh tvOS 11 beta. 4K HDR references have also appeared in iTunes.

Additionally, in March, developer Firi Games provided MacRumors with evidence of a device identified as "AppleTV6,2" and running "tvOS 11.0" connecting to its arcade game Phoenix HD for Apple TV in its logs. The IP address fell within a range linked to Apple's headquarters in Cupertino, California.

The current Apple TV has a model identifier of AppleTV5,3, and Apple TV6,2 does not correspond with any released model.

It's conceivable that Apple could launch 4K content in iTunes alongside a new Apple TV with support for up to 4K video output and HDR, or high dynamic range, which allows for sharper colors and lighting. The current, fourth-generation Apple TV has a maximum 1080p video output, and no support for HDR.

The high-end iMac models with 4K and 5K Retina displays are currently Apple's only devices that can display 4K content properly. The latest Apple TV lacks the hardware required for 4K and HDR video output.

Apple is widely expected to unveil new iPhones at a September event, which it could also use to unveil a new Apple TV.

Related Roundups: Apple TV, tvOS 10
Tag: Parks Associates
Buyer's Guide: Apple TV (Don't Buy)
Discuss this article in our forums

Taylor Swift and snakes: The backstory

CNN - 1 hour 54 min ago
With her blonde good looks, trademark red lipstick and hordes of devoted fans, what could Taylor Swift ever have in common with a slithery reptile?

Bungie prioritizing “simulation” over frame rate for console Destiny 2

Ars - 2 hours 27 sec ago

Our own Mark Walton plays Destiny 2 at 4K and 60fps on PC.

Here at Ars, we spend a lot of time talking about how developers deal with the trade-offs between resolution, frame rate, graphical detail, and simulation complexity they face at the top end of modern console and PC hardware. Quite often, the first-blush "wow factor" of more pixels and higher frame rates wins out in this constant balancing act. For Destiny 2, though, Executive Producer Mark Noseworthy says the team prioritized the complexity of the game itself over hitting a frame rate higher than 30fps.

In a Twitter thread back in June, Noseworthy said that the CPU limits on current consoles mean the game had to scale back to 30fps "to deliver D2's AI counts, environment sizes, and # of players." In the latest issue of Edge magazine (excerpted by WCCFTech), Noseworthy expands on the reasoning behind that choice:

It’s about the simulation of the Destiny world. Thirty AI at once, large open spaces, six players, sometimes with vehicles, and dropships coming in; that’s where we’re using the CPU.

Could we make a Destiny game that ran at 60fps? Yes, but the space would be smaller, it would be less cooperative, and there’d be fewer monsters to shoot. That’s not the game we want to make.

First and foremost, we’re trying to make an incredible action game. We don’t feel we’ve been held back by the choices we’ve made about world simulation versus frame rate; in fact, we think we’re offering a player experience you can’t have elsewhere because of the choices we’re making.

Put like that, the trade-off doesn't sound like a bad one. Yes, a game that's locked to 30fps looks markedly worse than one running at 60fps or more, all things being equal. The resulting lack of smoothness is especially noticeable in a reflex-based shooting game like Destiny 2 (though the server's internal tick rate has arguably more impact on how the game feels). That said, a smoother Destiny 2 with fewer simultaneous enemies and fewer player characters in smaller battle locales would probably be noticeably worse to play, too. As long as the game can run steadily at a playable 30 frames per second, without dips, that sounds like a perfectly acceptable trade.

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Trump on the media: ‘They are trying to take away our history and our heritage’

Washington Post - 2 hours 9 min ago
President Trump told his supporters in Phoenix on Aug. 22, that the media is "trying to take away our history and our heritage" and is giving a platform to hate groups.

Ariel—makers of the Atom—have a hybrid hypercar in the works

Ars - 2 hours 12 min ago

Ariel Motor Company

If you watch Top Gear, you'll know the Ariel Motor Company. It's the British maker of the Atom, a mid-engined assortment of scaffolding that was dreamt up as a modern answer to the Lotus/Caterham Seven—the same car that gave Jeremy Clarkson an epiglottis full of bees. Ariel also makes the Nomad, an off-road version of the Atom that featured in Matt Le Blanc's Top Gear debut.

Both of those vehicles are utterly bonkers, stripped down to the very essence of a car but overloaded with excitement. Which makes us rather excited about the fact that the next four-wheeled thrill ride to emerge from its Somerset factory is going to be an electric vehicle.

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Trump berates 'sick' news media

CNN - 2 hours 19 min ago
Think President Trump couldn't ratchet up his attacks on the news media any more than he already has?

In a Thriving City, SoHo’s Soaring Rents Keep Storefronts Empty

NY Times - 2 hours 20 min ago
One of the city’s prime shopping districts is a victim of its own success, as retailers can’t afford the rents and landlords can’t afford to lower them.

Samsung makes the Galaxy Note8 Official

Ars - 2 hours 24 min ago


NEW YORK CITY—We're live from New York, where Samsung has taken the wraps off its new flagship device, the Galaxy Note8.

Samsung changed everything about the Galaxy S line earlier this year, and those changes are all making the jump to the bigger Note model. You get an extra-tall display with on-screen navigation buttons and slim bezels. The fingerprint reader has been moved to the back, next to the camera components. There's also an iris scanner, a dedicated hardware button for Samsung's "Bixby" voice assistant, and compatibility with Samsung's "Dex" desktop dock.

Galaxy Note8 in Orchid Gray. (credit: Samsung)

So what is actually different from the Galaxy S8, which launched almost five months ago? Well, first, it's slightly bigger. While the Galaxy S8+ topped out at 6.2-inches, the Note 8 bumps up to 6.3-inches. On the back there's Samsung's first dual-camera design, pairing a wide-angle camera with a telephoto one with 2× optical zoom. Both have optical image stabilization, something Samsung claims is a first. Samsung has a number of trick features using the dual cameras, such as fine control over depth-of-field and simultaneous dual captures to take a whole-scene, wide-angle shot at the same time as taking a close-up, detailed shot.

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Shailene Woodley may run for office

CNN - 2 hours 26 min ago
Add actress Shailene Woodley to the list of celebs who are considering tossing their hats into the political ring.

Spanish Thrives in the U.S. Despite an English-Only Drive

NY Times - 2 hours 30 min ago
Thanks to migration, adaptation, pop culture and commerce, the Spanish language endures in the United States, regardless of any effort to control it.

Trump attacks McCain and Flake but says 'I will not mention any names'

Washington Post - 2 hours 39 min ago
President Trump issued scathing attacks against Arizona's senators during his Phoenix rally on Aug. 22, but said, "I will not mention any names. Very presidential."

Some people may be 'white supremacists by default'

CNN - 2 hours 41 min ago
Blame President Trump for his tepid moral response. Call the neo-Nazis and white nationalists thugs. Fill your Facebook and Twitter accounts with moral outrage.

A guide to New York's Central Park

CNN - 2 hours 44 min ago
Manhattan might be best known for its towering skyscrapers and bustling pavement, but there are few New York City locales more loved than the 843 acres of green that is Central Park.

Catholic priest reveals KKK past

CNN - 2 hours 46 min ago
A Catholic priest is temporarily stepping away from public ministry after writing in an op-ed that he was a member of the Ku Klux Klan decades ago.

Gut bacteria chemicals keep old animals young. Us, too?

Futurity.org - 2 hours 51 min ago

A class of chemicals, called indoles, made by intestinal bacteria help worms, flies, and mice stay mobile and resilient longer in their lives, report researchers.

“This is a direct avenue to a drug that could make people live better for longer,” says senior author Daniel Kalman, professor of pathology and laboratory medicine at Emory University School of Medicine.

“…people are living longer; but you might not really want to live longer if it means spending those extra years frail and infirm.”

Researchers use “health span” to describe the length of time a human or animal can stay active and resist stress while aging. For this study, the focus is on whether the animals live healthier—but not necessarily longer.

“We need a better understanding of health span,” Kalman says. “With medical advances, people are living longer; but you might not really want to live longer if it means spending those extra years frail and infirm.”

Recent studies with humans and mice and have shown that the spectra of bacteria in our bodies become narrower with age.

“We don’t always know how various microbiota exert their effects,” Kalman says. “But now we have a big clue to one mechanism.”

Indole, produced by many types of bacteria through a breakdown of the amino acid tryptophan, can smell noxious or flowery depending on the concentration. Indole and its chemical relatives can be found in plants, especially vegetables such as broccoli and kale.

Indole and related molecules have previously been identified as compounds released by E. coli bacteria that help the worm C. elegans and mice be more resistant to infection and other stresses.

Worms normally eat bacteria. So researchers fed them E. coli bacteria that produce indoles, and compared them with worms fed E. coli that don’t.

As they age, older worms spend less time moving around, can’t swallow as well, and are more sensitive to stressors. Although indoles didn’t increase lifespan, they markedly increased the amount of time the worms stayed mobile after the age of 15 days. Indoles also boosted swallowing strength and resistance to heat stress, even in young animals.

Further, worms usually stop reproduction at the age of 5 days, but dietary indole more than doubled their reproductive span, allowing them to remain fertile up to 12 days.

Will phages complicate quest for designer gut bacteria?

There was a similar effect on the mobility and heat resistance in Drosophila fruit flies—and a comparable pattern was evident in mice.

Researchers treated mice with antibiotics to eliminate the existing flora, and then re-colonized them with either normal E. coli, or, as a control, with bacteria that cannot produce indole.

“It’s like The Picture of Dorian Gray, in terms of the genes involved. Indoles make old animals look more like the young ones.”

In very old mice (28 months), indoles helped animals maintain their weight, mobility, and activity levels. In younger mice, indoles extended survival after exposure to lethal radiation.

The researchers also analyzed the patterns of gene activity affected by indoles – the genes regulated by indoles were distinct from other C. elegans genes previously linked to longevity.

“It’s like The Picture of Dorian Gray, in terms of the genes involved,” Kalman says. “Indoles make old animals look more like the young ones.”

Friends beat family for aging well

Kalman and colleagues are now investigating how indoles exert their effects in aging animals, how dysregulation of indoles produced by the microbiota contribute to frailty, and how they can be used to reverse these effects.

“Indole is such an ancient messenger,” Kalman says. “It’s how plants steer their growth, how bacteria talk to each other, and it is how plants and bacteria talk with us and ensure proper homeostasis with our immune system. It is perhaps not so surprising that these molecules help maintain our vitality.”

Postdoctoral fellow Robert Sonowal is first author of the study that appears in the Proceedings of the National Academy of Sciences.  The Bio-Merieux Foundation, the National Institute for Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging funded the work.

Source: Emory University

The post Gut bacteria chemicals keep old animals young. Us, too? appeared first on Futurity.

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