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Key cooperating witnesses in college admissions scam sign plea agreements

CNN - 4 hours 42 min ago
Mark Riddell and Rudy Meredith, two of the main cooperating witnesses in the college admissions scandal, have signed plea agreements with prosecutors in exchange for lesser sentences, according to court documents.

Buy an island in Sicily for $1.1 million

CNN - 4 hours 45 min ago
Isola delle Femmine is in the heart of a scuba diving and snorkeling mecca off the coat of Sicily. It could be yours from $1.1million.

Why New Zealand isn't a model for US gun reform

CNN - 4 hours 49 min ago
Americans rarely pay much attention to New Zealand. That changed over a week ago, following the alleged white supremacist attack on two mosques in the city of Christchurch. Within days, American media outlets were searching for lessons that could be drawn from these horrific events, with a particular emphasis on how the two countries have responded to mass shootings.

Trump again tries to pin the Mueller probe on Obama without providing evidence

Washington Post - 4 hours 56 min ago
There's no evidence that Obama was involved.

House Fails to Override Trump Veto, Preserving National Emergency Order

NY Times - 5 hours 6 min ago
The House failed to reach the two-thirds majority needed to overturn President Trump’s veto of a resolution that would have ended the national emergency declaration.

Can a stem cell trick get heart muscle to regenerate?

Futurity.org - 5 hours 7 min ago

Researchers have developed an approach to regenerate heart muscle using stem cells.

Their method for priming stem cells to become heart tissues could potentially enable heart regeneration stem cell therapies.

The self-regeneration of human heart muscle following injury is extremely limited. Scientists have been studying techniques to prompt different kinds of stem cells to differentiate into heart cell precursors, which could then help rebuild heart muscle fibers. However, their approaches have not yet met regulations set forth by the US Food and Drug Administration and the European Medicines Agency for regenerative therapies.

“Regulatory authorities specifically require these stem-cell-derived precursors be prepared from human-only cells and in cultures that use clearly defined chemicals and no animal components. The method must be reproducible, and the cells must have clear characteristics while not leading to adverse side effects when injected,” explains Lynn Yap, a senior research fellow at the Duke-NUS Cardiovascular and Metabolic Disorders Program and first author of a study in Cell Reports outlining the method.

In their work, researchers investigated using a heart muscle associated protein called laminin to promote the differentiation of human embryonic stem cells into heart cell precursors. Laminins attach to the outer parts of cell membranes and are thought to play a role in the differentiation of precursor cells into other types of cells. Several types of laminins exist.

Karl Tryggvason, professor in diabetes research at the CVMD Program, and his team produced laminin-221 in the laboratory by stimulating the human genes that code for this protein. The team then used Laminin-221 to coat a culture of pluripotent human embryonic stem cells. They also used laminin-521 to support the growth of the stem cells, and organic compounds called CHIR99021 to boost stem cell differentiation.

Their method led to stem cells differentiating into cardiovascular precursor cells. These included three main sub-populations: cardiac muscle-like cells, fibroblast-like cells, and epithelial-like cells; but did not include cells with a propensity to develop into tumors.

The team reproduced their method with very similar results using two stem cell lines two different laboratories generated decades apart by using different techniques.

Using an animal model, the researchers injected 9- and 11-day-old cardiovascular precursor cells into damaged heart tissue and found these precursor cells differentiated into cardiac muscle fiber bundles that survived in the heart for at least 12 weeks; heart functions also improved.

“These results suggest a role for the use of laminins in cardiac muscle cell differentiation, and may lead the development of clinical-quality cardiovascular progenitor cells for regenerative cardiology in humans,” says Tryggvason.

Future research will need to investigate the cell subpopulations that form with this technique to explore whether they can intensify new heart muscle growth in living animals.

Tryggvason is a co-founder and shareholder of Biolamina AB, the Swedish biotechnology company that holds the intellectual property for and produces the laminin-221 used in the study.

Source: Duke-NUS Medical School

The post Can a stem cell trick get heart muscle to regenerate? appeared first on Futurity.

Meet the largest Tyrannosaurus rex ever discovered

CNN - 5 hours 9 min ago
Paleontologists have discovered the biggest Tyrannosaurus rex fossil yet found, according to a new study. The fossil is also the largest dinosaur ever uncovered in Canada.

Yale rescinds admission of a student whose family paid $1.2 million to get her in

CNN - 5 hours 14 min ago
• Racketeering suspects all plead not guilty in college admissions scheme • Dr. Dre celebrates his daughter getting into USC 'on her own' years after his donation

How Microsoft found a Huawei driver that opened systems to attack

Ars - 5 hours 16 min ago

Enlarge (credit: Valentina Palladino)

Huawei MateBook systems that are running the company's PCManager software included a driver that would let unprivileged users create processes with superuser privileges. The insecure driver was discovered by Microsoft using some of the new monitoring features added to Windows version 1809 that are monitored by the company's Microsoft Defender Advanced Threat Protection (ATP) service.

First things first: Huawei fixed the driver and published the safe version in early January, so if you're using a Huawei system and have either updated everything or removed the built-in applications entirely, you should be good to go.

The interesting part of the story is how Microsoft found the bad driver in the first place.

Read 10 remaining paragraphs | Comments

Boeing is in crisis, but it is doing just fine in its race with Airbus

CNN - 5 hours 26 min ago
Boeing remains competitive with its biggest rival, Airbus, even as Boeing faces one of its worst crises ever.

Collusion Was a Seductive Delusion

NY Times - 5 hours 30 min ago
It's our own fault we elected Trump.

Smollett's case may still cast a shadow over his career

CNN - 5 hours 30 min ago
Jussie Smollett is about to test that old adage that any publicity is good publicity.

Trump’s latest response to Hurricane Maria victims provides insight into his views of Latinos

Washington Post - 5 hours 34 min ago
More than two years after taking office, the president continues to provide critics with new examples that shed light on where Latinos rank in importance to him

U.S. ITC Judge Says Apple Infringed on Qualcomm Patent, Import Ban Recommended [Updated]

MacRumors - 5 hours 35 min ago
A U.S. International Trade Commission judge today ruled that Apple has infringed on a Qualcomm patent with its iPhones, and has recommended that a limited exclusion order and a cease and desist order be issued against Apple.

According to the ruling, Apple violated claim 1 of U.S. Patent No. 8,063,674, "multiple supply-voltage power-up/down detectors." Apple did not violate two other patents that were involved in the case, with the infringement limited to the '674 patent.

The judge has recommended an import ban on infringing iPhones, which would prevent them from being sold in the United States.

As CNET points out, this is not a final ruling, and will need to be approved by a panel of judges before it moves on to presidential review.

This is one of two patent infringement rulings expected from the ITC in the ongoing Qualcomm vs. Apple legal battle. Back in September, an initial ruling in a second case also found that Apple infringed on a Qualcomm patent related to power management technology.

The judge in that case recommended against an import ban because of "public interest factors."

Qualcomm wants the ITC to ban imports of AT&T and T-Mobile iPhone 7, iPhone 7 Plus, iPhone 8, iPhone 8 Plus, and iPhone X models that use chips from Intel.

Qualcomm and Apple have been fighting in courts all over the world, and Qualcomm has successfully won import bans in China and Germany, which Apple has since skirted with software and hardware updates.

In the U.S., a jury recently found Apple guilty of infringing on three of Qualcomm's patents, recommending a fine of approximately $31 million in damages. Apple is appealing that ruling and the fight between the two companies is far from over.

Update: In a second patent infringement case that the ITC ruled on today [PDF], Apple was found not to have infringed on patented Qualcomm technology related to power management. This second ruling does not impact the first infringement ruling covered in the initial article.

Update 2: Apple provided Bloomberg with the following statement on the second ITC verdict: "We're pleased the ITC has found Qualcomm's latest patent claims invalid, it's another important step to making sure American companies are able to compete fairly in the marketplace. Qualcomm is using these cases to distract from having to answer for the real issues, their monopolistic business practices. They are being investigated by governments around the world for their behavior and we look forward to detailing the many ways they're harming consumers and stifling innovation when we present our case in San Diego next month."

Tag: Qualcomm
This article, "U.S. ITC Judge Says Apple Infringed on Qualcomm Patent, Import Ban Recommended [Updated]" first appeared on MacRumors.com

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House fails to override Trump's veto over national emergency wall fight

CNN - 5 hours 36 min ago
The House failed to override President Donald Trump's veto after both chambers of Congress sought to overturn his national emergency declaration to build more border wall.

Trump’s itchy Twitter finger creates another diplomatic mess

Washington Post - 5 hours 36 min ago
Trump said last week that he was eliminating just-announced sanctions on two Chinese companies who do business with North Korea. The scramble it reportedly set off has become oh so familiar within the administration.

What you need to know about Europe's new copyright law

CNN - 5 hours 37 min ago
Europe has approved new copyright laws that will change the internet. The problem is that nobody knows exactly how.

Pelosi: Barr believes Trump is 'above the law'

CNN - 5 hours 37 min ago
House Speaker Nancy Pelosi told House Democrats in a private meeting Tuesday that Attorney General William Barr's words cannot be taken at face value, according to multiple sources in the meeting, arguing Barr got the job in the first place by authoring a memo criticizing special counsel Robert Mueller's obstruction probe as "fatally misconceived."
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